A Study Evaluating the Immunotherapy Treatment for Ovarian Cancer and Other Advanced Malignancies. (NCT07389239) | Clinical Trial Compass
Not Yet RecruitingPhase 1/2
A Study Evaluating the Immunotherapy Treatment for Ovarian Cancer and Other Advanced Malignancies.
United States24 participantsStarted 2026-06-23
Plain-language summary
This phase I/IIA trial studies the side effects and best dose of gene-modified T cells when given with or without decitabine, and to see how well they work in treating patients with malignancies expressing cancer-testis antigens.
Who can participate
Age range18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adult subjects (18 years and older) with histologically or cytologically of advanced (metastatic or inoperable) advanced solid tumors.
* Tumor (either an archival specimen or a fresh biopsy) shows NY-ESO-1 expression of 1+ by IHC (H-score). NY-ESO-1 expression must be confirmed by central validated assay.
* Patients with NY-ESO-1 expressing solid tumors will be included. Patients must have received, been intolerant of, or been ineligible to receive at least 2 lines of the current standard of care therapy including but not limited to chemotherapy, immunotherapy and/or targeted therapy when appropriate (e.g. Atezolizumab is approved for use in patients with alveolar soft part sarcoma) according to their disease:
* Inoperable or metastatic (advanced) ovarian, primary peritoneal or fallopian tube carcinoma:
* Has received platinum containing chemotherapy and has platinum refractory or resistant disease that has progressed on second line therapy
* If platinum sensitive disease, should have received ≥2 lines of chemotherapy.
* May have received PARP inhibitors, bevacizumab or other targeted VEGF inhibitor therapy
* Inoperable or metastatic (advanced) soft tissue sarcoma:
* Subjects must have previously received either an anthracycline or ifosfamide containing regimen.
* Gastrointestinal stromal tumors are eligible, but only must have previously received KIT-targeted therapy if a sensitizing mutation is present.
* Angiosarcomas are eligible, but only must have…
What they're measuring
1
To evaluate autologous in the number of participants with treatment-related adverse events.