The goal of this study is to understand how chewing duration affects how quickly caffeine from caffeinated chewing gum appears in the blood and how long higher caffeine levels are maintained. The study compares two chewing durations (5 minutes and 10 minutes) in healthy men. Each participant attends two study visits on separate days at least 48 hours apart and completes both chewing conditions. At each visit, participants chew caffeinated gum that provides approximately 300 mg of caffeine. Blood samples are collected before chewing and at several time points for up to 3 hours after chewing to measure plasma caffeine levels. Researchers will compare the two chewing durations to determine whether chewing time changes peak plasma caffeine concentration, the time to reach the peak, overall exposure over 0 to 180 minutes, and the time that plasma caffeine remains near the peak level. The results may help guide practical timing of caffeinated gum use.
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Peak Plasma Caffeine Concentration (Cpeak)
Timeframe: From baseline (0 minutes) up to 180 minutes post-chewing
Time to Peak Plasma Caffeine Concentration (Tpeak)
Timeframe: From baseline (0 minutes) up to 180 minutes post-chewing
Area Under the Plasma Caffeine Concentration-Time Curve From 0 to 180 Minutes (AUC0-180)
Timeframe: 0 to 180 minutes post-chewing