Wound Healing and Bacterial Adherence With Triclosan-Coated Sutures After Mandibular Impacted Thi… (NCT07386366) | Clinical Trial Compass
RecruitingNot Applicable
Wound Healing and Bacterial Adherence With Triclosan-Coated Sutures After Mandibular Impacted Third Molar Surgery
Vietnam14 participantsStarted 2025-10-07
Plain-language summary
The goal of this clinical trial is to learn if triclosan-coated absorbable stitches (polyglactin 910 sutures coated with triclosan, an antibacterial agent) help soft tissue heal better and have fewer bacteria stuck to the stitches after lower impacted wisdom tooth surgery in adults aged 18 to 35 years.
The main questions it aims to answer are:
1. Does triclosan-coated polyglactin 910 suture lead to better soft-tissue wound healing than non-coated polyglactin 910 suture on postoperative days 3, 5, and 7 after mandibular impacted third molar surgery?
2. Does triclosan-coated polyglactin 910 suture result in a lower oral bacterial load adhered to the suture material than non-coated polyglactin 910 suture on postoperative days 3, 5, and 7 after mandibular impacted third molar surgery?
Participants will:
* Have surgery to remove two similar lower impacted wisdom teeth (one on each side)
* Receive triclosan-coated stitches on one side and standard stitches on the other side, with the side assignment chosen at random
* Return for follow-up visits on day three, day five, and day seven after surgery for healing checks, simple ratings of pain and swelling, and collection of a small stitch sample for bacterial testing.
Who can participate
Age range
18 Years – 35 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults aged 18 to 35 years.
* American Society of Anesthesiologists (ASA) physical status I or II.
* Presence of two symmetric impacted mandibular third molars with the same level of difficulty according to the Pell-Gregory and Winter classification; the difference in angulation between the two third molars is no more than 15 degrees.
* No use of topical or systemic antibiotics for at least 4 weeks before surgery.
* Able and willing to provide written informed consent.
* No active infection associated with the mandibular third molar at the time of enrollment.
Exclusion Criteria:
* Pregnant or breastfeeding.
* Allergy to local anesthetic (2% lidocaine with 1:100,000 epinephrine) or any medications used in the study.
* Radiographic findings suggestive of a tumor or cyst associated with the impacted mandibular third molar.
* Participant withdraws consent or does not agree to continue participation.
* Unable to attend scheduled follow-up visits.
* Difference in surgical extraction time between the two procedures is 12 minutes or more.
* Suture loss/loosening before completion of the final assessment time point.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Oral bacterial load on suture material (real-time PCR)
Timeframe: Postoperative days 3, 5, and 7 after each surgery (period 1 and period 2).
Trial details
NCT IDNCT07386366
SponsorUniversity of Medicine and Pharmacy at Ho Chi Minh City