Carotid Doppler Parameters and Post-Induction Hypotension
Turkey (Türkiye)91 participantsStarted 2025-03-01
Plain-language summary
Post-induction hypotension is a common complication following the induction of general anesthesia and is associated with adverse postoperative outcomes. Patients undergoing gynecologic oncology surgery represent a particularly vulnerable population due to advanced age, high comorbidity burden, and increased frailty, which may predispose them to perioperative hemodynamic instability.
This prospective observational study aims to evaluate whether carotid Doppler ultrasonography parameters, including corrected flow time and other flow-related indices, can predict the occurrence of post-induction hypotension specifically in patients undergoing gynecologic oncology surgery.
Adult patients scheduled for elective gynecologic oncology surgery under general anesthesia will undergo pre-induction carotid Doppler ultrasonography as part of routine perioperative assessment. Baseline clinical characteristics, including the Charlson Comorbidity Index and Clinical Frailty Scale, will be recorded for each participant. Hemodynamic parameters will be recorded following anesthetic induction, and the development of post-induction hypotension will be assessed.
The findings of this study may help identify high-risk patients within the gynecologic oncology population and support the use of non-invasive carotid Doppler measurements, comorbidity burden, and frailty assessment for perioperative risk stratification in this specific surgical group.
Who can participate
Age range
18 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Female patients aged 18 years or older
* Scheduled for elective gynecologic oncology surgery under general anesthesia
* Planned standard anesthetic induction
* Ability to provide written informed consent
Exclusion Criteria:
* Refusal to participate in the study
* Inability to obtain informed consent, including patients with dementia
* Emergency surgery
* American Society of Anesthesiologists (ASA) physical status IV or higher
* Cardiac rhythm other than sinus rhythm
* Autonomic nervous system disorders
* Atrial fibrillation with rapid ventricular response
* Pregnancy
* Sepsis or septic shock
* Significant valvular heart disease or peripheral vascular disease
* Anticipated difficult ventilation and/or difficult intubation
* Left ventricular ejection fraction \<40%
* Severe aortic valve stenosis
* Morbid obesity (body mass index \>40 kg/m²)
* Presence of implanted cardiac pacemaker or implantable cardioverter-defibrillator
* Chronic beta-blocker therapy
* Baseline mean arterial pressure \<65 mmHg at admission
* Baseline systolic arterial blood pressure \>190 mmHg or diastolic arterial blood pressure \>110 mmHg
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Occurrence of Post-Induction Hypotension
Timeframe: Within the first 20 minutes after induction of general anesthesia