Efficacy and Safety of Topical Timolol in Secondary Intention Surgical Wounds Healing (NCT07384767) | Clinical Trial Compass
Not Yet RecruitingPhase 2
Efficacy and Safety of Topical Timolol in Secondary Intention Surgical Wounds Healing
United States220 participantsStarted 2026-06-01
Plain-language summary
The purpose of this research study is to evaluate the efficacy and safety of topical timolol 0.5% for secondary intention wound healing following 1) Mohs micrographic surgery, 2) standard surgical excision, OR 3) electrodesiccation and curettage (ED\&C). Please note that healing by secondary intention refers to when a wound heals naturally without surgical closure.
To evaluate the efficacy of topical timolol 0.5%, 220 participants will be recruited. Participants will be placed into one of two groups: The treatment group or the control group.
1. The treatment group will receive a topical timolol 0.5% solution, which will be applied to their wound daily for 12 weeks.
2. The control group will receive standard care with the addition of hydrogel, which will also be applied to their wound daily for 12 weeks.
During this 12-week period, both groups will be required to upload photos of their wound healing to their MyChart account at weeks 3, 6, 9, and 12. These photos will be reviewed by the investigator to assess wound healing. Re-epithelialization and earlier complete wound healing will be compared between both groups to determine the efficacy of topical timolol 0.5% solution compared to the standard of care.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. Male or female subject of any race 18 years old or older
✓. Patient opt to heal by secondary intention healing after discussion of reconstructive options following excision
✓. Patients undergoing Mohs micrographic surgery, standard surgical excision, or electrodesiccation and curettage (ED\&C) whose wounds are managed by secondary intention healing.
✓. Willing to send photos of ulcer at 3 week intervals with ruler measuring length by width
✓. Able to give informed consent themselves
Exclusion criteria
✕. Cyst excisions (due to concern for inflammation)
✕. Site shows evidence of infection (defined as a moderate or severe rating of all of the following clinical signs/symptoms: 1) increased warmth, 2) increased pain, 3) erythema, and 4) malodorous exudate at Screening or at Randomization (Visit 1), OR total organism count \> 1 x 105 colony forming units (CFU) from the screening visit study ulcer culture sample)