Adjuvant Clopidogrel in Staphylococcus Aureus Bacteremia

Inclusion Criteria: To be eligible, patients must meet the same criteria as those of the general SNAP platform, as well as the domain-specific criteria: * Microbiological isolation: Presence of Staphylococcus aureus complex in at least one blood culture. * Hospitalization status: The patient must be admitted to a participating hospital at the time of eligibility assessment. * Time window: Eligibility assessment must be completed within 72 hours after collection of the initial blood culture. Exclusion Criteria: General Medical and Safety Factors: * Allergies: Known hypersensitivity to thienopyridines (clopidogrel, prasugrel, ticlopidine). * Clinical status: Inability to tolerate or take oral medications, and severe hepatic impairment (Child-Pugh Class C). * Pregnancy: Pregnant or breastfeeding women. High Risk of Bleeding or Hematologic Disorders: * Active or recent bleeding: Significant bleeding or invasive procedures within the previous 7 days. * Planned surgeries: Requirement for major surgical intervention within 10 days following study enrollment. * Coagulation parameters: Platelet count \<50,000/mm³ or known coagulation disorders. * Concomitant medications: Patients already receiving regular aspirin therapy, other P2Y12 inhibitors, or therapeutic-dose anticoagulants (prophylactic-dose heparin is permitted). Specific Diagnoses and Clinical Criteria: * Endocarditis: Confirmed diagnosis or clinical suspicion of bacterial endocarditis. Sources indicate that exclusio…