Hydrocortisone and Fludrocortisone for the Treatment of Septic Shock

Exclusion criteria

• ✕. Systemic corticosteroid therapy within the last 3 months before septic shock;
• ✕. High-dose steroid therapy;
• ✕. Immunosuppression;
• ✕. Pregnant;
• ✕. Known allergy to hydrocortisone or fludrocortisone;
• ✕. Presence of gastrointestinal bleeding, perforation, or other conditions requiring fasting;
• ✕. Anticipated death from a preexisting disease within 90 days after randomization (as determined by the enrolling physician);
• ✕. Refusal of the attending staff or patient family;