By InvitationNot Applicable

GastroFlow: Investigation of the Gastrointestinal Blood Flow in Patients With Postprandial Hypotension

Denmark30 participantsStarted 2025-09-15

Plain-language summary

This project will describe the mechanisms of action and the relative contributions of GIP to changes in gastrointestinal blood flow induced by oral glucose and endogenous GIP with the use of a receptor antagonists GIP(3-30)NH2 in patients with postprandial hypotension.

Who can participate

Age range

18 Years – 90 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

For the PPH group Inclusion Criteria: * Postprandial hypotension * Symptoms of postprandial hypotension Exclusion Criteria: * Treatment with drugs that cannot be paused for 12 hours * Metallic implants that does not tolerate MRI * Any other disease or dysfunction that may disturb blood flow to the gut * Intake of more than 14 units of alcohol per week or abuse of drugs * Blood vessels that are not feasible for measuring flow in the MRI scanner * Low blood percent * Decreased kidney function * Decreased liver function * Claustrophobia For the healthy group Inclusion Criteria: * Matched by age, gender and BMI Exclusion Criteria: * Postprandial hypotension * Metallic implants that does not tolerate MRI * Intake of more than 14 units of alcohol per week or abuse of drugs * Blood vessels that are not feasible for measuring flow in the MRI scanner * Low blood percent * Decreased kidney function * Decreased liver function * Claustrophobia * Autonomic dysfunction or other disease that cause changes in blood pressure during or after a meal * Intake of pharmaceutical products that influence the blood pressure

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Blood flow

Timeframe: 145 minutes

Trial details

NCT IDNCT07381816

SponsorUniversity of Copenhagen

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-12-01

View on ClinicalTrials.gov More Postprandial Hypotension trials

Who can participate

Age range

18 Years – 90 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.