GastroFlow: Investigation of the Gastrointestinal Blood Flow in Patients With Postprandial Hypote… (NCT07381816) | Clinical Trial Compass
By InvitationNot Applicable
GastroFlow: Investigation of the Gastrointestinal Blood Flow in Patients With Postprandial Hypotension
Denmark30 participantsStarted 2025-09-15
Plain-language summary
This project will describe the mechanisms of action and the relative contributions of GIP to changes in gastrointestinal blood flow induced by oral glucose and endogenous GIP with the use of a receptor antagonists GIP(3-30)NH2 in patients with postprandial hypotension.
Who can participate
Age range18 Years – 90 Years
SexALL
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For the PPH group
Inclusion Criteria:
* Postprandial hypotension
* Symptoms of postprandial hypotension
Exclusion Criteria:
* Treatment with drugs that cannot be paused for 12 hours
* Metallic implants that does not tolerate MRI
* Any other disease or dysfunction that may disturb blood flow to the gut
* Intake of more than 14 units of alcohol per week or abuse of drugs
* Blood vessels that are not feasible for measuring flow in the MRI scanner
* Low blood percent
* Decreased kidney function
* Decreased liver function
* Claustrophobia
For the healthy group
Inclusion Criteria:
* Matched by age, gender and BMI
Exclusion Criteria:
* Postprandial hypotension
* Metallic implants that does not tolerate MRI
* Intake of more than 14 units of alcohol per week or abuse of drugs
* Blood vessels that are not feasible for measuring flow in the MRI scanner
* Low blood percent
* Decreased kidney function
* Decreased liver function
* Claustrophobia
* Autonomic dysfunction or other disease that cause changes in blood pressure during or after a meal
* Intake of pharmaceutical products that influence the blood pressure