Active — Not RecruitingNot Applicable

High-Flow Nasal Cannula Versus Non-Invasive Ventilation for Acute Respiratory Failure in Pulmonary Embolism.

Egypt100 participantsStarted 2025-10-01

Plain-language summary

Acute pulmonary embolism (PE) often causes hypoxemic respiratory failure through ventilation-perfusion mismatch and right-ventricular (RV) strain; supportive oxygenation plus prompt anticoagulation are crucial to care . Current guidelines advise supplemental oxygen and escalation according to hemodynamic/respiratory status, but do not identify an optimal noninvasive modality for PE-related respiratory failure.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: \- 1. Age ≥18 y; presented with acute PE confirmed by CTPA or high-probability V/Q. 2\. AHRF needing non-invasive support; provided that patients able to protect airway and hemodynamically stable without escalating vasopressors Exclusion Criteria: * 1\. Immediate indication for intubation; high-risk (massive) PE with shock requiring advanced airway/vasopressors; active major bleeding; untreated pneumothorax. 2\. Contraindications/intolerance to assigned modality (e.g., facial trauma for NIV; complete nasal obstruction for HFNC). 3\. Do-Not-Intubate orders; pregnancy ; concomitant respiratory failure primarily due to another process requiring a different pathway.

What they're measuring

Weaning success at 48 h

Timeframe: 48 hours

Trial details

NCT IDNCT07381712

SponsorAssiut University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-10-30

View on ClinicalTrials.gov More Pulmonary Embolism trials