Deep Breathing With and Without Pressure Support and PEEP for Preoxygenation in Obese Patients (NCT07380425) | Clinical Trial Compass
CompletedNot Applicable
Deep Breathing With and Without Pressure Support and PEEP for Preoxygenation in Obese Patients
Turkey (Türkiye)75 participantsStarted 2021-12-01
Plain-language summary
Obese patients are at increased risk of low oxygen levels during the induction of general anesthesia. Preoxygenation with a face mask before anesthesia is routinely used to increase oxygen reserves. This study compares three preoxygenation techniques: deep breathing alone, deep breathing with pressure-supported ventilation, and deep breathing with pressure-supported ventilation plus positive end-expiratory pressure (PEEP).
The main goal of the study is to determine how quickly each technique allows patients to reach an adequate level of oxygen in the lungs. In addition, the study evaluates whether these techniques cause gastric distension, which could increase the risk of regurgitation. Gastric ultrasound is used to assess stomach size before and after preoxygenation.
The results of this study will help identify the most effective and safest method of preoxygenation in obese patients undergoing elective surgery.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age ≥ 18 years
* Obesity
* Scheduled for elective surgery under general anesthesia
* Able to cooperate with deep breathing during preoxygenation
Exclusion Criteria:
* Hemodynamic instability
* Poor cooperation
* Preoperative oxygen therapy requirement
* Conditions in which positive pressure ventilation may be harmful (e.g., increased intracranial or intraocular pressure)
* Pregnancy
* Emergency surgery
* Beard (preventing adequate face mask seal)
* Previous gastric surgery
* Inability to visualize the gastric antrum by ultrasonography
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Time to reach an end-tidal oxygen concentration (EtO₂) of 90%
Timeframe: Periprocedural (during the preoxygenation period, prior to induction of anesthesia)