This decentralized, randomized, double-blind, placebo-controlled, two-period crossover study will evaluate whether PepZinGIĀ® (zinc-L-carnosine) reduces food-triggered heartburn compared with placebo. Participants (N=50) complete two 1-week treatment periods (PepZinGIĀ® and placebo) separated by a 2-week washout, for a total of 29 days. Primary outcomes are heartburn severity and frequency measured by the NutriScience Heartburn Questionnaire; secondary outcomes include PROMIS GI Reflux-13a, time to relief, rescue medication use, wearable-derived sleep metrics, Karolinska Sleep Scale, sleep diary entries, and satisfaction. All activities are remote through Alethios; no in-person visits.
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Heartburn frequency measured by PROMIS-Gastroesophageal Reflux 13a
Timeframe: Baseline, Day 8, and Day 29
Participant sleep quality measured by Karolinska Sleep Scale
Timeframe: Baseline, Day 8, and Day 29
Heartburn severity measured by NutriScience Heartburn Questionnaire
Timeframe: Day 8 and Day 29