Neoadjuvant Therapy for Early Triple-Negative Breast Cancer: A Response-Guided Approach Using Iparomlimab and Tuvonralimab Injection in Combination With Chemotherapy

Inclusion Criteria: * Voluntarily join this study, sign the informed consent form, and demonstrate good compliance; * Age: 18-75 years old (at the time of signing the informed consent form); * ECOG PS score: 0-1; expected survival time exceeding 6 months; * Patients with primary breast cancer confirmed by histopathological or cytological examination; * Primary tumor diameter \> 2 cm as measured by local standard assessment methods; * Judged by the investigator to meet the American Joint Committee on Cancer (AJCC) 8th edition breast cancer TNM staging criteria as cT2-cT4, cN0-cN3, cM0, with locally advanced or early-stage, unilateral, and histologically confirmed invasive breast cancer; * Histopathologically confirmed early-stage triple-negative invasive breast cancer as defined by the latest ASCO/CAP guidelines; * At least one measurable lesion according to RECIST 1.1; * The patient agrees to undergo breast cancer resection surgery when meeting the surgical criteria after neoadjuvant therapy; * PD-L1 expression status is known; * Major organ functions are in good condition; * Female subjects of childbearing potential must have a negative serum pregnancy test within 3 days prior to the first dose. If a female subject of childbearing potential engages in sexual activity with a non-sterilized male partner, the subject must use acceptable and effective contraception from screening onward and agree to continue these precautions until 12 months after the last dose of the study dru…