CompletedNot Applicable

Prism Adaptation Therapy for CRPS Type 1

Turkey (Türkiye)54 participantsStarted 2023-10-04

Plain-language summary

Complex Regional Pain Syndrome (CRPS) is a clinical condition characterized by pain that arises either without an identifiable triggering factor or with a severity disproportionate to the initiating event. Its progression is typically unpredictable, and most therapeutic interventions yield only partial efficacy. Prism Adaptation Therapy (PAT) is a sensorimotor training method traditionally employed to mitigate attentional deficits in post-stroke hemispatial neglect and has recently been explored as a treatment modality for CRPS. Preliminary non-blinded studies with small patient cohorts have demonstrated its potential to reduce pain and related symptoms. The present study aims to assess the effects of prism adaptation therapy administered during the acute phase on pain intensity and other clinical outcomes in CRPS, addressing the considerable challenges associated with managing chronic pain in this disorder.

Who can participate

Age range18 Years – 75 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria * Individuals aged between 18 and 75 years * Patients diagnosed with CRPS Type 1 according to the IASP 2003 CRPS Budapest diagnostic criteria * Presence of traumatic etiologies, including surgical procedures, fractures, or immobilization * Patients who consented to participate and provided written informed consent Exclusion Criteria * History of inflammatory, autoimmune, hematologic, or neoplastic diseases * Diabetes mellitus, thyroid disorders, hepatic or renal failure * History of cranial trauma or cranial surgery within the preceding 6 months * Use of diuretics, anti-inflammatory, antineoplastic, corticosteroid, immunosuppressive, antidepressant, or anxiolytic medications within the past 2 months * Use of anticholinergic medications within the past 7 days * Active ocular infection, inflammation, allergy, or recent use/exposure to ophthalmic drops * History of lens or ocular surgery within the last 3 months * Current or previous use of glasses or contact lenses, or diagnosis of refractive error ≥0.5 diopters * Peripheral nerve injury in the affected hand consistent with CRPS Type 2 as per Budapest criteria * Known progressive or non-progressive peripheral or central nervous system disorders * CRPS Type 1 developing subsequent to central nervous system injury (e.g., stroke) * Patients in the acute phase following primary or secondary tendon repair * Presence of comorbid conditions likely to impair functionality and health-related quality of life, such a…

What they're measuring

Visual Analog Scale (VAS)

Timeframe: Baseline, post-treatment (Week 4), and follow-up (Week 10)

LANNS

Timeframe: Baseline, post-treatment (Week 4), and follow-up (Week 10)

Trial details

NCT IDNCT07370012

SponsorAnkara Etlik City Hospital

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2024-05-30