The Influence of Chemotherapy on Position Sense (NCT07367711) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
The Influence of Chemotherapy on Position Sense
Belgium145 participantsStarted 2026-02
Plain-language summary
Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most prevalent side-effects of chemotherapy, causing sensory and motor symptoms in patients. CIPN development is especially prevalent in chemotherapy treatment involving platinum- and taxane-based agents. The accompanying pain and deficits greatly impact the quality of life of these patients. Currently, patients are assessed for altered somatosensory using quantitative sensory testing (QST). The German Research Network on Neuropathic Pain (DFNS) has developed a standardized protocol which has been internationally recognized as approach for performing the QST. However, for proprioception the QST is limited to vibration assessments, making it limited as the only test to measure proprioception. Therefore, a comprehensive assessment of the proprioceptive functions is needed to better understand the influence CIPN has on the proprioception of patients, and thereby their quality of life.
In this project the effects of chemotherapy on somatosensory and proprioceptive functioning of breast cancer patients will be assessed in a cross-sectional study. This will be tested by comparing two groups of breast cancer patients and a healthy control group. Both patient groups will have undergone surgery for breast cancer, however, only one group will be tested after undergoing additional chemotherapy treatment. Thereby, the effects of chemotherapy between the surgery-only patient group and the chemotherapy patient group can tested. Furthermore, the investigators will compare both patient groups to sex- and age-matched healthy controls.
Who can participate
Age range
18 Years – 75 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria
General (applies to all participants):
* At least 18 years of age at the time of signing the informed consent form
* Voluntary written informed consent of the participant has been obtained prior to any screening procedures
Breast cancer surgery-only patient group:
* The patient is an adult oncological person between 18 and 75 years old who has been treated for cancer
* The participant has undergone breast cancer surgery but has not received any radiotherapy or chemotherapy treatment (yet).
* The first session takes place between two and six weeks after breast cancer surgery.
* The second session takes before any follow-up treatment for breast cancer (radiotherapy or chemotherapy).
Chemotherapy group:
* The patient is an adult oncological person between 18 and 75 years old who has been treated for cancer.
* The participant has undergone breast cancer surgery but has not received any radiotherapy (yet).
* Participant has a history of treatment with platinum- or taxane-based chemotherapeutic agents, and this treatment has been terminated no later than 6 weeks before the first session.
Healthy control group:
* No history of cancer or chemotherapy treatment
* Sex and age-matched to patient sample
Exclusion Criteria:
General (applies to all participants):
* Participant has a history of mental or physical disorders or neurological disease beyond those related to cancer treatments.
* Participant uses any prescription or non-prescription drugs on a regula…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Proprioceptive variability
Timeframe: Baseline (across two assessment visits within 10 days of each other)