Effect of Esketamine on Perioperative Negative Emotions in Patients Undergoing Breast Cancer Surgery (NCT07367542) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Effect of Esketamine on Perioperative Negative Emotions in Patients Undergoing Breast Cancer Surgery
China218 participantsStarted 2026-01-17
Plain-language summary
A Dual-Center, Randomized, Controlled, Blinded, Prospective Study on the Effects of Esketamine on Perioperative Negative Emotions in Patients Undergoing Breast Cancer Surgery
Who can participate
Age range18 Years
SexFEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Age ≥ 18 years.
✓. Scheduled to undergo elective breast cancer resection surgery.
✓. American Society of Anesthesiologists (ASA) physical status classification of I-III.
✓. Clearly understand and voluntarily agree to participate in the study, and sign the informed consent form.
✓. Anticipated anesthesia duration greater than 90 minutes.
Exclusion criteria
✕. Patients with significant preoperative abnormalities in cardiac, pulmonary, hepatic, or renal function, or coagulation disorders .
✕. Patients taking antipsychotics, antidepressants, or glucocorticoids, or with a history of alcohol abuse or illicit drug use .
✕. Patients with an MMSE score \<18, dementia, intellectual disability, or those unable to communicate (e.g., coma, severe dementia, hearing or language impairment) .
✕. Patients with a history of psychiatric or neurological disorders (e.g., schizophrenia, epilepsy, Parkinson's disease, or severe myasthenia gravis) .
✕. Patients with poorly controlled or untreated hypertension (≥180/110 mmHg) .
✕. Patients with elevated intracranial or intraocular pressure.
✕. Patients with untreated or inadequately treated hyperthyroidism .
What they're measuring
1
Perioperative anxiety and depreession
Timeframe: Preoperative day 1, postoperative day 3, day 7 and day 30