Nifedipine and Enalapril vs Nifedipine and Labetalol for the Treatment of Postpartum Hypertension… (NCT07363343) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Nifedipine and Enalapril vs Nifedipine and Labetalol for the Treatment of Postpartum Hypertension Study
200 participantsStarted 2026-02-01
Plain-language summary
To determine if nifedipine and enalapril will have better blood pressure control in the postpartum setting compared to nifedipine and labetalol.
Who can participate
Age range18 Years
SexFEMALE
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Postpartum women aged 18 years or older
* Clinical diagnosis of hypertensive disorder in pregnancy (gestational hypertension, chronic hypertension, preeclampsia with or without severe features)
* Taking Nifedipine 60 mg every 12 hours for blood pressure control
* Persistently elevated blood pressure at/above 140/90 mmHg in a 24-hour time period or have one or more severe range blood pressure at/above 160/110 mmHg requiring a second antihypertensive medication
* English speaking
Exclusion Criteria:
* Taking ≥2 antihypertensive agents during pregnancy
* Heart block
* Heart rate \<60 or \>120 beats per minute
* Heart failure
* Creatinine \>1.5 mg/dL
* Renal artery stenosis
* Active connective tissue disease
* Cerebrovascular accident
* Failed treatment or contraindications to nifedipine, enalapril or labetalol
What they're measuring
1
Composite postpartum hypertension treatment failure within 6 weeks postpartum