Prevention of Reperfusion Injury Outcomes Through Effective Cardioprotection Targeting Myocardial Infarction

Inclusion Criteria: * Have provided informed consent. * Male patients aged 40 to 75 years of age.- Female patients aged 55 to 75 years of age, or women aged 40 to 55 years that have no possibility of being pregnant. * Patient presents with first-time STEMI, scheduled to undergo primary PCI within 6 h of symptom onset and anticipated door to balloon time \< 2 h. * In combination with symptoms consistent with acute MI, patient must demonstrate ST-elevation at the J-point in two contiguous leads. * Hemodynamically stable including: systolic BP ≥ 90 mmHg, HR 50-120 bpm. * Killip Class I or II. * Oxygen saturation ≥ 92% on room air or low-flow oxygen. * No ongoing VT/VF at enrolment. * Male participants with female partners of child-bearing potential must be ready and able to use highly effective methods of birth control for at least 7 days following IP administration. Exclusion Criteria: * History or ECG evidence of myocardial infarction or cardiomyopathy. * Prior major cardiac surgery, including but not limited to coronary artery bypass graft surgery (CABG). * Known contraindication to CMR (e.g. pacemakers, cochlear implants, aneurism clips, claustrophobia, allergy to contrast medium). * History of clinically significant renal impairment requiring dialysis or an estimated glomerular filtration rate \<30 mL/min. * Estimated or known body weight \< 50 kg, \> 120 kg at screening. * Concurrent enrolment in another investigational device or drug trial, or less than 30 days or 5 ha…