RecruitingNot Applicable

SweetSpot - The Effect of Non-nutritive Sweeteners on Health

Netherlands60 participantsStarted 2026-02-23

Plain-language summary

The aim of the study is to investigate the effect of non-nutritive sweeteners on glucose regulation. Secondary objectives are to investigate the effect of NNS on gut microbiome, gut hormone secretion, sweet taste sensitivity and preference, and the excretion of NNS in urine.

Who can participate

Age range

45 Years – 79 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age 45-79 years; * BMI of 20-35 kg/m2; * Having veins suitable for placement of a venflon catheter. Exclusion Criteria: * Diseases or prior surgeries affecting the stomach, liver, kidneys or intestines (allowed i.e. appendectomy); * Cardiovascular diseases (e.g. heart failure) or cancer (e.g. non-invasive skin cancer allowed); * Diagnosed with type 1 or type 2 diabetes; * Drug treated thyroid diseases (well substituted hypothyroidism is allowed for inclusion); * HbA1c level \>6.5% (\>48 mmol/mol), as measured during the screening visit; * Anaemia defined as Hb concentrations \<8.5 mmol/L for men and \<7.5 mmol/L for women via finger prick; * Regular use of/receiving medication interfering with research outcomes (as judged by research physician), such as use of glucose lowering drugs, insulin, or use of medication that impacts the gastro-intestinal system; * Use of antibiotics over the last 3 months before study start; * Donated blood within 2 months prior to the screening; * Food allergies, intolerances (including lactose/gluten intolerance) for products used in the study design and/or dietary restrictions interfering with the study (including special diets and eating disorders); * Followed a diet that can interfere with the study outcomes within 1 month prior to the screening (e.g. ketogenic, sugar free, carbohydrate free); * Not willing to eat all products in the study diet, including eggs and dairy. Vegetarian is possible; * Not willing to consume …

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Difference in change in 2h iAUC glucose after 6 weeks between the intervention and the control.

Timeframe: Week 2 and week 8 in both intervention periods (4 times in total)

Trial details

NCT IDNCT07361406

SponsorWageningen University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-11-26

View on ClinicalTrials.gov More Healthy Adult trials

Who can participate

Age range

45 Years – 79 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.