High-frequency Alternating Current Stimulation for Neurophatic Pain in Spinal Cord Injury (NCT07359677) | Clinical Trial Compass
CompletedNot Applicable
High-frequency Alternating Current Stimulation for Neurophatic Pain in Spinal Cord Injury
Spain30 participantsStarted 2026-01-30
Plain-language summary
To investigate the safety and effectiveness of transcutaneous electrical stimulation with 40 kHz alternating currents combined with standard treatment compared to placebo electrical stimulation plus standard treatment for neuropathic pain in people with spinal cord injury.
Who can participate
Age range18 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* People with spinal cord injuries of any aetiology affecting the D1 spinal cord level or lower (paraplegia)
* With injury grade A, B, C, or D according to the ASIA (American Spinal Injury Association) Impairment Scale (AIS)
* Time since spinal cord injury ≥ 3 months
* A score of ≥ 4 points on the Dolour Neuropathique 4 (DN4) scale
* Neuropathic pain at the level of the injury (within the dermatome at that level and up to three dermatomes below) and/or below the level of the injury (more than three dermatomes below)
* Duration of pain ≥ 1 month
* Average pain perception score ≥ 30 mm on the visual analogue scale (VAS) in the week prior to eligibility, with a daily record of 5 days (Monday to Friday) in the morning.
* Be able to understand instructions and assessment tools
* Agree to participate in the study and sign the informed consent form
Exclusion Criteria:
* Cauda equina injuries
* Brain injuries or other central nervous system injuries concomitant with spinal cord injury
* A value of 100 mm in any of the daily records collected in the week prior to eligibility
* Having any contraindications for the application of transcutaneous electrical stimulation: cardiac pacemaker or any other implanted electrical device, epilepsy, pregnancy, active malignant tumours in the area of application of the stimulation, and wounds or skin damage in the area of stimulation
* History of psychiatric illness
* Major depression
* Spinal cord injury caused by autolysis
* …
What they're measuring
1
Pain perception - NPSI
Timeframe: Prior to the intervention (Baseline), during the intervention after five sessions (Day 5), after the intervention (Day 10) and one week after the end of the intervention (Day 15)