A Comparative Clinical Study Assessing Dentin Thickness and Discoloration in Deep Carious Lesions… (NCT07358442) | Clinical Trial Compass
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A Comparative Clinical Study Assessing Dentin Thickness and Discoloration in Deep Carious Lesions Treated With Biodentine Alone Versus Diode Laser Pre-treatment Followed by Biodentine
Egypt48 participantsStarted 2025-07-30
Plain-language summary
This interventional clinical study aims to compare dentin thickness preservation and tooth discoloration in deep carious lesions treated with Biodentine alone versus diode laser pre-treatment followed by Biodentine. Participants with deep carious lesions will be allocated to one of two treatment protocols, and clinical and radiographic assessments will be performed to evaluate outcomes. The findings of this study may provide evidence on whether diode laser pre-treatment offers additional clinical benefits when used prior to Biodentine application in the management of deep caries.
Who can participate
Age range18 Years – 45 Years
SexALL
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Inclusion criteria
✓. Patients aged \[ 18-45 years\] requiring treatment for a single deep carious lesion and willing to provide informed consent and comply with follow-up appointments. Candidates with good general health.
✓. tooth-related criteria included reversible pulpitis or asymptomatic restorable vital permanent posterior molar. (based on clinical and radiographic examination, pulp vitality tests).
✓. Radiographic evidence of deep caries approaching the pulp (e.g., inner half of dentin).
✓. No signs of irreversible pulpitis or periapical pathology.
Exclusion criteria
✕. Patients undergoing orthodontic treatment or with significant periodontal disease affecting the study tooth or who cannot tolerate CBCT scanning.
✕. patients who are medically compromised (systemic diseases affecting bone metabolism or healing (e.g., uncontrolled diabetes)).
✕. pregnant ladies, patients with allergy to any component of Biodentine or other materials used, and patients who are not cooperative.
. Tooth-related criteria involved teeth that have irreversible pulpitis or necrotic pulp (based on symptoms and vitality tests; spontaneous pain, or sustained pain after vitality tests (electrical or cold tests), teeth with pain on percussion ).
✕. Teeth with periapical radiolucency and have been already restored before (previous endodontic treatment)
✕. Extensive tooth destruction requiring full coronal coverage.