A Study of Retatrutide (LY3437943) in Participants Without Type 2 Diabetes Who Have Obesity or Ov… (NCT07357415) | Clinical Trial Compass
Active — Not RecruitingPhase 3
A Study of Retatrutide (LY3437943) in Participants Without Type 2 Diabetes Who Have Obesity or Overweight
United States, Argentina, Canada600 participantsStarted 2026-01-24
Plain-language summary
The purpose of this study is to investigate the efficacy and safety of different retatrutide dose escalation schemes in participants without type 2 diabetes who have obesity or overweight. Participation in the study will last about 113 weeks.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Have a Body Mass Index (BMI) at screening
* ≥ 30 kilogram per square meter (kg/m2) OR
* ≥ 27 kg/m2 with presence of at least one of the following weight-related conditions at screening: high blood pressure, abnormal levels of lipid, obstructive sleep apnea, heart disease
* Have at least one unsuccessful attempt to lose weight by dieting
Exclusion Criteria:
* Have a self-reported change in body weight \>5 kilograms (kg) (11 pounds) within 90 days before screening
* Have a prior or planned surgical treatment for obesity
* Have type 1 diabetes or type 2 diabetes
* Have a family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2)
* Have had within the past 90 days before screening:
* heart attack
* stroke
* hospitalization for unstable angina or heart failure
* Have New York Heart Association Functional Classification Class IV congestive heart failure
* Have a history of chronic or acute pancreatitis
* Have taken weight loss drugs, including over-the counter medications within 90 days prior to screening
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This is a Phase 3 trial for retatrutide in people with obesity or overweight who don't have Type 2 diabetes — does my specific health profile and weight history make this worth discussing as an option compared to treatments already available to me?
2Since the trial is listed as 'active, not recruiting,' does that mean enrollment is already closed, and if so, are there any similar studies or expanded access programs for retatrutide that I might still be eligible for?
3The main thing being measured is percent change in body weight from the start — what does my doctor know so far about how much weight loss retatrutide has shown in earlier phases, and what that might realistically mean for someone in my situation?
4Because this is a Phase 3 trial, more safety data exists than in earlier phases, but the drug isn't fully approved yet — are there any side effects or risks that have emerged so far that I should seriously weigh before considering this?
5Would my doctor recommend I try an already-approved weight management medication or program first, and how would that compare to what a trial like this might offer me?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.