Herpes zoster is caused by the reactivation of latent varicella-zoster virus (VZV) which stays in latency after its primary infection. Immunosenescence contributes significantly to elevating morbidity associated with aging. Vaccination plays a key role in reducing the disease burden of zoster and the associated complications. We are conducting a study entitled "A Randomized, Blinded, Placebo- and Active-Controlled, Adaptive Phase 2 Clinical Trial to Evaluate the Immunogenicity and Safety of SYS6017 (a Herpes Zoster mRNA Vaccine) in Healthy Participants Aged 40 Years and Above".
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solicited adverse events
Timeframe: within 14 days post each vaccination
unsolicited adverse events
Timeframe: within 30 days post each vaccination
Geometric Mean Concentration (GMC) of anti-gE antibody
Timeframe: On Day 14 and Day 30 after the completion of the full vaccination course
Geometric Mean Fold Increase (GMFI) of anti-gE antibody
Timeframe: On Day 14 and Day 30 after the completion of the full vaccination course
Seroconversion Rate (SCR) of anti-gE antibody
Timeframe: On Day 14 and Day 30 after the completion of the full vaccination course
Clinical Trials Information Group officer