Cigarette Filter Study (NCT07348679) | Clinical Trial Compass
RecruitingNot Applicable
Cigarette Filter Study
United States252 participantsStarted 2026-04-27
Plain-language summary
The overall purpose of this study is to determine the effects of using charcoal-filtered cigarettes on product perceptions, smoking behaviors, and biomarkers of exposure to tobacco-related toxicants. The main questions it aims to answer are:
Do perceptions of cigarettes differ by their filter? Do people smoke charcoal-filtered cigarettes differently than cigarettes with conventional filters, and does this change their exposure to cigarette harms?
Study participants will complete a 5-week laboratory-based, open-label, parallel-design randomized trial. After a baseline period of smoking their preferred brand, participants will smoke charcoal-filtered or non-charcoal-filtered cigarettes for 4 weeks while completing weekly sessions to assess primary outcomes. During weekly sessions, they will smoke two cigarettes in our laboratory, provide urine and carbon monoxide samples, and complete questionnaires.
Who can participate
Age range
21 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Male and female smokers who are at least 21 years of age and self-report smoking at least 5 cigarettes per day for at least the past 6 months.
. Smokers of primarily non-menthol cigarettes of brands other than Natural American Spirit.
. Not currently undergoing smoking cessation treatment or trying to quit.
. Able to communicate fluently in English (speaking, writing, and reading).
. Capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the combined consent and HIPAA form.
Exclusion criteria
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Risk beliefs
Timeframe: Day 35
2
Perceived health risks
Timeframe: Day 35
3
Subjective ratings
Timeframe: Day 35
4
Daily cigarette consumption
Timeframe: Day 35
5
Smoking topography (puffs taken)
Timeframe: Day 35
6
Smoking topography (total duration)
Timeframe: Day 35
7
Smoking topography (total interpuff interval)
Timeframe: Day 35
8
Session onset carbon monoxide (CO)
Timeframe: Day 35
9
Trial details
NCT IDNCT07348679
SponsorRutgers, The State University of New Jersey
. Use of menthol or Natural American Spirit cigarettes as preferred/regular brand (defined as using \>20% of the time).
. Enrollment or plans to enroll in a smoking cessation program in the next month.
. Provide an initial Carbon Monoxide (CO) reading \< 5 parts per million (ppm).
. History of substance abuse (other than nicotine) in the past 12 months and/or currently receiving medical treatment for substance abuse.
. Current alcohol consumption that exceeds 25 standard drinks/week.
. Women who are pregnant, planning a pregnancy, and/or lactating.
. Any impairment including, but not limited to, visual, physical, and/or neurological impairments preventing the completion of procedures included within this protocol. Notable impairments will be evaluated by the PI and eligibility will be determined on a case-by-case basis.