Rifampin-free Regimen Versus Rifampin-containing Regimen in the Treatment of Staphylococcal Prosthetic Valve Endocarditis

Inclusion Criteria: * Definite infective endocarditis according to the 2023 Duke ISCVID criteria or confirmed by the endocarditis team if the endocarditis was classified as possible * Prosthetic valve endocarditis * At least one positive blood culture due to Staphylococcus sp (S. aureus or CoNS) * After the first positive blood culture, at least one negative blood culture (after a minimum of 72 hours of incubation) * Infective endocarditis due to Staphylococcus sp (S. aureus or coagulase negative staphylococci) susceptible to rifampin * Antistaphylococcal treatment for endocarditis introduced less than 14 days ago. We do not consider all antibiotic received before the first positive blood culture * Age ≥ 18-year-old * Informed, written consent obtained from patient or from patient's near in kin * Patient insured under a health insurance scheme * Patient with adequate contraceptive measure Exclusion Criteria: * Presence of cardiovascular implanted electronic device with suspected device-related IE without removal of the device * Expected duration of follow-up \<6 months at the time of randomization * Patient moribund (expected to die in next 48 hours with or without treatment) * Patients already receiving more than 72 hours of rifampin for the endocarditis treatment prior to randomization * Positive blood cultures less than 72 hours before randomization * Medical history of infective endocarditis in the last 3 months * True allergy to rifampin or a severe intolerance to rif…