CompletedNot Applicable

Comparison of the Effects of N-acetylcysteine, Calcium Hydroxide, and Double Antibiotic Paste

Turkey (Türkiye)45 participantsStarted 2022-09-10

Plain-language summary

This study aimed to evaluate the efficacy of N-acetylcysteine (NAC) used as an intracanal medicament on antibacterial activity, periapical RANKL/OPG ratio, and postoperative pain levels.

Who can participate

Age range

18 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Non-vital teeth confirmed by clinical and pulp sensitivity tests * Teeth with a single canal and diagnosed with asymptomatic apical periodontitis * Periapical assessment (PAI) of 2 or greater * Teeth with a pocket depth not exceeding 3 mm * Teeth without excessive root curvature (Schneider class 1) and with visible root canals on radiographs * Permanent teeth with complete root development * Patients between the ages of 18 and 65 * Teeth without previous endodontic treatment Exclusion Criteria: * Patients who refused to participate in the study * Patients with any systemic disease * Patients who received antibiotic treatment within the last 3 months * Patients who were pregnant or suspected of being pregnant * Teeth with excessive crown damage that would not allow for the placement of a rubber dam * Teeth with root fractures, pathological findings or mobility, * Presence of any resorption in the involved tooth, * Patients with active swelling and tenderness to palpation.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Antibacterial efficacy of intracanal medicaments, RANKL/OPG ratio and effect on postoperative pain

Timeframe: The medication will remain in the canal for one week. Patients will receive treatment within one month.

Trial details

NCT IDNCT07340944

SponsorAtaturk University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-01-09

View on ClinicalTrials.gov More Chronic Apical Periodontitis trials

Who can participate

Age range

18 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.