Clinical Study of EZH2 Inhibitor Combined With PARP Inhibitor in the Treatment of Patients With A… (NCT07339553) | Clinical Trial Compass
Not Yet RecruitingPhase 2
Clinical Study of EZH2 Inhibitor Combined With PARP Inhibitor in the Treatment of Patients With Advanced or Recurrent Epithelial Ovarian Cancer.
30 participantsStarted 2026-01-04
Plain-language summary
This study evaluates the efficacy and safety of Zeprumetostat in combination with Fuzuloparib for the treatment of patients with advanced or recurrent ovarian epithelial carcinoma, with the primary endpoint being Objective Response Rate (ORR).
Who can participate
Age range18 Years – 75 Years
SexFEMALE
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Inclusion Criteria:
* Age between 18 and 75 years.
* Histologically or cytologically confirmed ovarian carcinoma with FIGO Stage III-IV disease, or recurrent ovarian epithelial carcinoma (any stage or timing of recurrence), with genetic testing results indicating BRCA1/2 wild-type.
* At least one measurable lesion according to Response Evaluation Criteria in Solid Tumors version 1.1 (computed tomography scan showing the longest diameter of a non-lymph node tumor lesion is no less than 10 millimeters, or the short axis of a lymph node lesion is no less than 15 millimeters), or abnormal cancer antigen 125 levels, or presence of ascites, as confirmed by the investigator.
* Eastern Cooperative Oncology Group (ECOG) Performance Status score between 0 and 2; expected survival of at least 3 months.
* Adequate function of major organs, with screening laboratory test results meeting the following requirements:
Complete Blood Count criteria must be met:
A. Hemoglobin ≥ 80 grams per liter; B. Absolute neutrophil count ≥ 1.5 × 10⁹ per liter; C. Platelet count ≥ 80 × 10⁹ per liter.
Biochemistry criteria must meet the following standards:
A. Total bilirubin \< 1.5 times the upper limit of normal; B. Alanine aminotransferase and aspartate aminotransferase \< 2.5 times the upper limit of normal, and \< 5 times the upper limit of normal for patients with liver metastases; C. Serum creatinine ≤ 1.5 times the upper limit of normal or endogenous creatinine clearance \> 60 milliliters per mi…