he RenewDisc Trial is a prospective observational clinical study evaluating outcomes in patients with confirmed discogenic low back pain who undergo standard clinical care using endoscopic spine procedures. The study observes and compares clinical, functional, and imaging outcomes following endoscopic discectomy, endoscopic discectomy combined with autologous mesenchymal stem cell therapy, or standalone endoscopic application of autologous mesenchymal stem cells. Participants are treated according to routine clinical decision-making, and no interventions are assigned by the study protocol. Data are collected prospectively at predefined follow-up intervals to assess pain intensity, functional disability, quality of life, and structural changes on magnetic resonance imaging.
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Oswestry Disability Index (ODI)
Timeframe: From baseline to 24 months after the procedure
Change From Baseline in Numerical Rating Scale (NRS) for Back Pain
Timeframe: From baseline to 24 months after the procedure
Change From Baseline in Visual Analog Scale (VAS) for Leg Pain
Timeframe: From baseline to 24 months after the procedure
Magnetic Resonance Imaging (MRI) Assessment of Intervertebral Disc Morphology
Timeframe: At 6, 12, and 24 months after the procedure