By InvitationNot Applicable

The Effect of Photobiomodulation on Microvascular Blood Flow: The Role of Wavelength and Skin Temperature

Israel40 participantsStarted 2026-01

Plain-language summary

The objective of this study is to assess peripheral microcirculatory hemodynamic responses to photobiomodulation in participants with normal circulation and with functional peripheral vasoconstriction, using noninvasive thermography, photoplethysmography, and laser Doppler flowmetry.

Who can participate

Age range20 Years – 75 Years

SexALL

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Inclusion criteria

✓. Healthy males and females, between 20 and 75 years of age.
✓. Willing to sign informed consent.
✓. Willing to participate in two separate sessions, one for each wavelength.
✓. Able to avoid caffeine and alcohol for at least 3 hours before each session.
✓. Able to sit comfortably with both hands at heart level for the full measurement duration.

Exclusion criteria

✕. Currently smoking
✕. Any abnormal skin condition in the area of light irradiation.
✕. Pregnant, having given birth less than 3 months ago, and/or breastfeeding.
✕. History of photosensitive conditions or use of photosensitizing medications
✕. Suffering from significant concurrent illness, such as cardiac disorders or pertinent neurological disorders.
✕. As per the Investigator's discretion, any physical or mental condition that might make it unsafe for the subject to participate in this study.

What they're measuring

Capillary blood flow

Timeframe: Up to 1 hour

Trial details

NCT IDNCT07338695

SponsorAfeka, The Tel-Aviv Academic College of Engineering

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-12

View on ClinicalTrials.gov More Microcirculation trials