Propofol vs Remifentanil for Sedation in Gastroscopy (NCT07336628) | Clinical Trial Compass
CompletedNot Applicable
Propofol vs Remifentanil for Sedation in Gastroscopy
Turkey (Türkiye)80 participantsStarted 2026-02-02
Plain-language summary
This prospective randomized study aims to compare propofol and remifentanil for sedation during elective diagnostic gastroscopy. The ideal sedative agent for gastroscopy should provide adequate sedation, rapid recovery, patient safety, and high endoscopist satisfaction. Although propofol is widely used for procedural sedation, remifentanil's ultra-short pharmacokinetic profile may offer advantages in short procedures such as gastroscopy. However, comprehensive comparative data evaluating recovery quality, safety, and procedural conditions between these agents remain limited. This study evaluates sedation efficacy, recovery characteristics, complication rates, and endoscopist satisfaction associated with propofol- and remifentanil-based sedation protocols.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age ≥18 years
* ASA physical status I-III
* Scheduled for elective diagnostic gastroscopy
* Able to provide informed consent
Exclusion Criteria:
* ASA IV-V
* Pregnancy or lactation
* Known allergy to propofol, remifentanil, or midazolam
* Severe cardiopulmonary disease (NYHA III-IV, unstable angina, severe COPD requiring home oxygen)
* Chronic opioid use (\>3 months daily use)
* BMI \>40 kg/m²
* Obstructive sleep apnea requiring CPAP
* Severe hepatic or renal impairment
* Inability to provide informed consent
* Emergency procedures
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Recovery Time
Timeframe: From the end of the gastroscopy procedure until achievement of discharge criteria, assessed up to 2 hours
2
Incidence of Sedation-Related Complications
Timeframe: From the start of sedation induction until discharge from the recovery area, assessed up to 2 hours
Trial details
NCT IDNCT07336628
SponsorFatih Sultan Mehmet Training and Research Hospital