This is a first time in Asia (FTIA) study designed to evaluate the safety, tolerability, pharmacokinetic (PK) and immunogenicity of efimosfermin alfa to healthy participants of Chinese, Japanese, and White/European ancestry.
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Number of participants with Adverse Events (AEs), treatment related AEs and serious adverse events (SAEs)
Timeframe: Up to 90 days
Number of participants with clinically significant changes in hematology, chemistry and urinalysis parameters
Timeframe: Up to 90 days
Number of participants with clinically significant changes in 12 Lead electrocardiogram (ECG)
Timeframe: Up to 90 days
Number of participants with clinically significant changes in vital signs
Timeframe: Up to 90 days
Area under the serum drug concentration versus time curve from time zero to the time of the last quantifiable concentration (AUC[0-t]) of efimosfermin alfa
Timeframe: Up to 90 days
Area under the serum drug concentration versus time curve from time zero extrapolated to infinity (AUC[0-inf]) of efimosfermin alfa
Timeframe: Up to 90 days
Maximum observed serum drug concentration, determined directly from the serum concentration-time data (Cmax) of efimosfermin alfa
Timeframe: Up to 90 days