Impact of Pilates Exercises on Bone Mineral Density in Breast Cancer Survivors Receiving Hormonal… (NCT07334626) | Clinical Trial Compass
RecruitingNot Applicable
Impact of Pilates Exercises on Bone Mineral Density in Breast Cancer Survivors Receiving Hormonal Therapy
Egypt60 participantsStarted 2026-01-01
Plain-language summary
Breast cancer survivors receiving endocrine (hormonal) therapy (aromatase inhibitors) are at high risk for cancer treatment-induced bone loss and osteoporosis due to estrogen depletion.
Who can participate
Age range40 Years – 60 Years
SexFEMALE
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Inclusion criteria
✓. Female breast cancer survivors aged 40-60 years.
✓. Histologically confirmed stage I-III breast cancer.
✓. Currently receiving hormonal therapy (aromatase inhibitors) for at least 3 months.
✓. At risk of osteoporosis or with low bone mineral density (BMD) defined by T-score ≤ -1.0 at lumbar spine or hip.
✓. Medically cleared for exercise, specifically low-to-moderate intensity Pilates.
✓. Able to attend supervised exercise sessions three times per week for 12 weeks.
✓. Willing and able to provide written informed consent.
Exclusion criteria
✕. Metastatic (stage IV) or recurrent breast cancer.
✕. History of osteoporotic fractures in the past 12 months.
✕. Severe cardiovascular, respiratory, or musculoskeletal conditions that contraindicate exercise.
✕. Uncontrolled hypertension, diabetes, or thyroid disorders.
✕. Current use of corticosteroids.
✕. Active bone metabolic disease other than osteoporosis (e.g., Paget's disease, osteomalacia).