Active — Not RecruitingPhase 4

Hyperbaric Bupivacaine Versus Hyperbaric Prilocaine in Spinal Anaesthesia

Singapore50 participantsStarted 2024-05-17

Plain-language summary

Prilocaine numbs you for a shorter time, allowing you to regain movement quicker, which helps you recover faster, start rehab sooner, and feel more satisfied with your treatment overall.

Who can participate

Age range21 Years – 90 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * undergoing elective unilateral total knee replacement * Able to give informed consent Exclusion Criteria: * Patients of age \< 21 or \> 90 years old * American Society of Anaesthesiologists (ASA) physical status\> III * Extremes of weight: \<40kg or BMI \>40 * Contra-indications to spinal anaesthesia, prilocaine or bupivacaine (including allergy to local anaesthesia agents or patients at high risk for methaemoglobinemia) * Complex TKR as deemed by surgeons * Patient refusal * Failure of spinal anaesthesia resulting in conversion to general anaesthesia, prior to start of operation * Patients with prostate hyperplasia or urogenital pathologies * Planning to conceive / pregnant women / breastfeeding

What they're measuring

Duration of Motor Block

Timeframe: Measured from the time of spinal anesthesia administration until full motor recovery, expected within 24 hours post-operation.

Trial details

NCT IDNCT07329582

SponsorNational University Hospital, Singapore

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-12-01

View on ClinicalTrials.gov More Knee Replacement, Total trials