The goal of this clinical trial is to create a machine learning algorithm to improve active repetitive transcranial magnetic stimulation (rTMS) treatments for veterans and/or active military personnel by alleviating Gulf War Illness related headaches and body pain (GWI-HAP). This study aims to develop and validate a Support Vector Machine (SVM) model that could replace the trial-and-error process by assessing functional connectivity provided by resting state functional magnetic resonance imaging (rs-fMRI) data to predict the most effective rTMS protocol for each person. All participants will be receiving active rTMS treatment. The main questions it intends to answer are: 1. Does the SVM model predict a more effective treatment response rate for predicted respondents undergoing active rTMS at the left dorsolateral prefrontal cortex (DLPFC) compared to predicted non-respondents? 2. Does the SVM model predict a more effective treatment response rate while undergoing active rTMS at the left dorsolateral prefrontal cortex (DLPFC) and left motor cortex (LMC) in predicted respondents compared to predicted non-respondents? Participants will undergo the following: 1. Receive a total of 13 active rTMS treatment sessions over 3-4 months. 2. Visit the clinic for a total of 15 visits for assessments, check ups, and treatments. 3. Keep a daily log of their headaches, muscle and joint pain throughout the study.
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Pain Intensity - Mechanical Visual Analogue Scale (M-VAS)
Timeframe: From baseline to the end of treatment at 16 weeks
Headache and Pain Log
Timeframe: From enrollment to the end of treatment at 16 weeks
Mood - Hamilton Rating Scale for Depression (HRSD)
Timeframe: From baseline to end of treatment at 16 weeks
Pain Severity - Brief Pain Inventory-Short Form (BPI-sf)
Timeframe: Baseline, 1-week, 1-month, 2-months
Pain Severity - Brief Pain Inventory-Short Form (BPI-sf)
Timeframe: Baseline, 1-week, 1-month, 2-months
Pain Quality and Intensity - Short Form McGill Pain Questionnaire (SF-MPQ)
Timeframe: Baseline, 1-week, 1-month, 2-months
Pain Quality and Intensity - Short Form McGill Pain Questionnaire (SF-MPQ)
Timeframe: Baseline, 1-week, 1-month, 2-months
Functionality - Revised Fibromyalgia Impact Questionnaire
Timeframe: Baseline, 1-week, 1-month, 2-months
Pain Intensity - New Clinical Fibromyalgia Diagnostic Criteria - Part 1
Timeframe: Baseline, 1-week, 1-month, 2-months
Pain Severity - Headache Impact Test (HIT-6)
Timeframe: Baseline, 1-week, 1-month, 2-months
Pain Severity - Neurobehavioral Symptoms Inventory (NSI)
Timeframe: Baseline, 1-week, 1-month, 2-months
Sleep Quality - Pittsburgh Sleep Quality Index (PSQI)
Timeframe: Baseline, 1-week, 1-month, 2-months
Sleep Severity - Insomnia Severity Index
Timeframe: Baseline, 1-week, 1-month, 2-months
Quality of Life - Veteran RAND 36-item Health Survey (VR-36+PCS and MCS)
Timeframe: Baseline, 1-week, 1-month, 2-months
Multidimensional Fatigue Inventory
Timeframe: Baseline, 1-week, 1-month, 2-months
Chronic Fatigue Severity Scale
Timeframe: Baseline, 1-week, 1-month, 2-months