Chemotherapy With or Without IMD10 (Focused Ultrasound) in the Treatment of Borderline Resectable or Locally Advanced Pancreatic Cancer

Inclusion Criteria: * An individual must meet all the following criteria: * 1\. Willing and able to understand and sign an ICF and to comply with all aspects of the protocol * 2\. Aged between 18 and 85 years, inclusive * 3\. Histologically or cytologically, pathologically confirmed diagnosis of PDAC. * 4\. Classification as BRPC or LAPC according to the NCCN Guidelines (The latest Edition) by radiologic test (CT or MRI), eligible for chemotherapy regimen within 4 weeks of the screening visit * 5\. Must have at least 1 measurable lesion per RECIST 1.1 criteria at the screening visit. * 6\. The ECOG performance status 0 or 1 * 7\. Trial participant having laboratory values defined as: Neutrophil count ≥ 1.5 x 10\^9/L, Platelet count ≥ 100 x 10\^9/L, AST and ALT ≤ 2.5 x ULN, - Serum creatinine ≤ 1.5 x ULN * 8\. Life expectancy is more than 12 weeks * 9\. A female is eligible to trial participate if not pregnant, not breast feeding and either a woman not of childbearing potential or, if a woman of childbearing potential agrees to use highly effective methods of contraception\* from screening to EOS * 10\. A male trial participant with female partner(s) of childbearing potential agrees to use highly effective methods of contraception from screening to EOS Exclusion Criteria: * An individual who meets any of the following criteria will be excluded from participating in this clinical trial: * 1\. The presence of a cystic lesion within tumor to be treated, or at the pancreas adja…