RecruitingNot Applicable

The Role of Electroencephalography in Caffeine Discontinuation Timing in Premature Infants

Turkey (Türkiye)100 participantsStarted 2026-01-02

Plain-language summary

The aim of this observational study is to investigate whether functional maturation assessment by electroencephalography in preterm infants can provide reliable data for the safe discontinuation of caffeine therapy without recurrence of apnea. In preterm infants receiving caffeine therapy, an assessment of maturation will be performed by EEG at the time when discontinuation of caffeine treatment is planned.

Who can participate

Age range1 Month

SexALL

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Inclusion criteria

✓. Infants born before 28 weeks of gestation with a birth weight of 1250 grams or less, who received prophylactic caffeine therapy.
✓. Infants with a birth weight greater than 1250 grams and a gestational age below 32 weeks, who required invasive mechanical ventilation and were started on prophylactic caffeine therapy.
✓. Infants born at less than 37 weeks of gestation, admitted to the neonatal intensive care unit, and treated with caffeine for apnea of prematurity.
✓. Infants whose parents or legal guardians provided informed consent.

Exclusion criteria

✕. Infants who did not receive caffeine therapy,
✕. Infants for whom an EEG could not be performed,
✕. Infants with major congenital malformations such as neuromuscular disorders, central nervous system developmental abnormalities, thoracic malformations, or major cardiac anomalies,
✕. Infants who were transferred to another facility within one week before or after discontinuation of caffeine therapy.

What they're measuring

Assessment of apnea risk after discontinuation of caffeine therapy in preterm infants.

Timeframe: From enrollment to the end of treatment at 4 weeks

Trial details

NCT IDNCT07324941

SponsorUludag University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2027-01-02

Contact for this trial

Salih Çağrı Çakır

+90 533 3453739 salihcagri@uludag.edu.tr

View on ClinicalTrials.gov More Apnea Neonatal trials