A Study to Assess Nicotine Uptake From Electronic Nicotine Delivery Systems

Inclusion criteria

• ✓. Smokes at least 10 cigarettes per day (on average) and inhales the smoke, for at least 6 months prior to Screening. Brief periods of abstinence due to illness, quit attempt (more than 30 days prior to Screening), or clinical study participation (more than 30 days prior to Screening) will be allowed at the discretion of the Principal Investigator (PI).
• ✓. Dual user of cigarettes and ENDS who self-reports:
• ✓. Surgical sterilization (hysterectomy, bilateral tubal ligation/occlusion, bilateral oophorectomy, bilateral salpingectomy);
• ✓. Physical barrier method (e.g., condom, diaphragm/sponge/cervical cap) with spermicide;
• ✓. Non-hormone-releasing intrauterine devices (IUDs) or hormone-releasing IUDs (e.g., Mirena or Kyleena);
• ✓. Vasectomized partner;
• ✓. Post-menopausal and not on hormone replacement therapy; or
• ✓. Sexual abstinence, defined as refraining from intercourse, when this is in line with the preferred and usual lifestyle of the participant.