Effects of Different Inspiratory:Expiratory Ratios on Respiratory and Recovery Outcomes During De… (NCT07323420) | Clinical Trial Compass
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Effects of Different Inspiratory:Expiratory Ratios on Respiratory and Recovery Outcomes During Dental Procedures Under General Anesthesia in Pediatric Patients
Turkey (Türkiye)75 participantsStarted 2026-04-01
Plain-language summary
This observational study aims to evaluate the effects of different inspiratory to expiratory (I:E) ratios (1:2 vs. 1:3) during mechanical ventilation in pediatric patients undergoing dental procedures under general anesthesia. Due to behavioral challenges, dental phobia, or medical conditions, general anesthesia is often required to ensure immobility and cooperation during dental treatments in children.
In the clinic where the study will be conducted, the I:E ratio is routinely adjusted approximately 20-30 minutes before the end of the procedure to facilitate a smoother transition to spontaneous breathing during emergence from anesthesia. While 1:2 is commonly used, the 1:3 ratio may improve respiratory efficiency and recovery by prolonging the expiratory phase.
The study aims to compare vital signs, respiratory parameters (heart rate, blood pressure, SpO₂, EtCO₂, respiratory rate), recovery quality, and respiratory complications between the two I:E ratios. The findings aim to optimize ventilation strategies and improve patient comfort and safety during emergence from anesthesia.
Who can participate
Age range
2 Years – 12 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Pediatric patients scheduled for dental procedures under general anesthesia at our faculty.
* American Society of Anesthesiologists (ASA) Physical Status I or II.
* Age between 2 and 12 years.
* Written informed consent obtained from parents or legal guardians.
Exclusion Criteria:
* Patients whose parents or legal guardians decline participation.
* Presence of adenoid hypertrophy \>30%.
* Macroglossia or retrognathia.
* Severe obesity or developmental delay.
* History of delayed emergence from anesthesia.
* ASA Physical Status III or higher.
* Anesthesia duration less than 1 hour or more than 3 hours.
* Patients with difficult airway management or ventilation.
* Known pulmonary or airway diseases or anomalies.
* Use of pharmacological agents that may affect spontaneous respiratory quality.
* Presence of neuromuscular disorders affecting respiratory function.
* Age \<2 years or \>12 years.
* Administration of medications intraoperatively or preoperatively that may influence respiratory dynamics during emergence (e.g., atropine, lidocaine, steroids).
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Post-Extubation Respiratory Quality
Timeframe: During 10 minutes after extubation
2
Respiratory Rate (RR)
Timeframe: During the emergence preparation period (approximately 25-35 minutes prior to extubation, up to 40 minutes if required)
3
Peak Airway Pressure (PeakP)
Timeframe: During the emergence preparation period (approximately 25-35 minutes prior to extubation, up to 40 minutes if required)
4
Heart Rate
Timeframe: During the emergence preparation period (approximately 20-30 minutes prior to extubation, up to 40 minutes if required)
5
Blood Pressure
Timeframe: During the emergence preparation period (approximately 20-30 minutes prior to extubation, up to 40 minutes if required)