Dihydroberberine Effects on Body Composition and Metabolic Health in Healthy Adults

Inclusion Criteria: * 35 - 55 years of age (inclusive) at visit 1. * BMI ≥ 27.0 - ≤ 33.0 kg/m2. * Participant has a score of 7 - 10 on the Vein Access Scale Assessment at visit 1. * Non-user or former user (daily use; cessation ≥12 months) of tobacco or nicotine products (e.g., cigarette smoking, vaping, chewing tobacco) within 12 months of visit 1, and has no plans to begin use during the study period. * Non-habitual users (i.e., daily or almost daily) of marijuana or hemp products, including CBD/THC products, and willing to abstain from use throughout the study period (topical creams/lotions are allowed). * Willing to use personal smart phone with operating system capable of downloading and operating study applications (e.g., FitBit, smart scale, activity watch, etc). * Willing to adhere to all study procedures, including lifestyle considerations (see section 6.3), and sign forms providing informed consent to participate in the study and authorization to release relevant protected health information to the Clinical Investigator. Exclusion Criteria: * Extreme dietary habits (e.g., ketogenic, very high protein, very high fiber, vegan/vegetarian) at the discretion of the Clinical Investigator. * Individuals undergoing moderate-to-intense activity (e.g., sports/exercise ≥ 5h/wk). * Recent weight changes (\>4.5 kg ≤ 90 d of visit 1), or current/planned engagement in a weight change program (e.g., weight loss or muscle gain) outside of the researcher-instructed, self-directed …