Role of Glucagon-like Peptide-1 Receptor Agonists in Menstrual Irregularities in Adolescent Females With Type 1 Diabetes Mellitus

Inclusion Criteria: * Diagnosis of Type 1 Diabetes Mellitus according to ISPAD criteria * Use of continuous glucose monitoring (CGM) * Receiving regular insulin therapy * Regular follow-up at a diabetes clinic * Female participants aged 12 to 18 years * At least 2 years post-menarche * Poor glycemic control, defined as HbA1c ≥ 7% Exclusion Criteria: * Presence of medical conditions known to cause menstrual irregularities, including:(Connective tissue disorders, Autoimmune diseases, Clinical thyroid dysfunction, Neurological diseases). * History of severe hypoglycemia within the past 12 months * Other causes of abnormal uterine bleeding, including:(Structural causes (e.g., leiomyoma, endometrial polyp), Coagulation disorders, Ovulatory disorders (e.g., hyperprolactinemia, hyperandrogenism), Iatrogenic causes (e.g., steroid therapy, oral contraceptive use) * Family history of medullary thyroid carcinoma or multiple endocrine neoplasia History of pancreatitis