Meropenem vs Azithromycin Efficacy in Case XDR Enteric Fever

Inclusion Criteria: * Participants will enrolled on following criteria * Voluntarily sign the written informed consent * Patient's of age 1-70 years with clinically suspected on physician decision or XDR enteric fever confirmed by blood culture and sensitivity tests. * Married females with negative pregnancy test. * No history of cardiac issues with ECG abnormalities, cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use. * Patients having no hypersensitivity (skin rashes, anaphylaxis) to azithromycin and meropenem * Patients on concomitant medication, having no drug-drug interaction with meropenem and azithromycin will be included in study. Exclusion Criteria: * Participants will excluded on following criteria * Pregnant, lactating women or women of childbearing age with positive pregnancy test at baseline. * Patients with known hypersensitivity (skin rashes, anaphylaxis) to azithromycin, meropenem, or any other macrolide or carbapenem antibiotics. * Blood culture and sensitivity tests reported positive culture with MDR S. typhi (non-susceptibility to at least one agent in three or more antimicrobial categories,) o * Patients with history of cardiac disorder with ECG abnormalities and history of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use will be excluded. * Patients on continuous medication, having drug-drug interaction with meropenem and azithromycin will be excluded.