Using Near-Infrared Light to Better Understand Peripheral Artery Disease (NCT07313410) | Clinical Trial Compass
RecruitingNot Applicable
Using Near-Infrared Light to Better Understand Peripheral Artery Disease
United States120 participantsStarted 2025-11-01
Plain-language summary
The goal of this study is to better understand how blood flows and how oxygen is utilized in the lower limbs of people who suffer from peripheral artery disease. This study will also assess how these factors affect treatment outcomes.
Specific aims include:
Aim 1: Utilize BB-NIR-DCS to differentiate PAD patients experiencing primary oxygen delivery limitations from those suffering from mitochondrial dysfunction.
Aim 2: Test the efficacy of BB-NIR-DCS at predicting individual responses to vascular intervention.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. 18 or older
✓. willing to participate under the conditions described in the informed consent form (ICF)
✓. eligible to sign the ICF
✓. established diagnosis of PAD confirmed by a physician
✓. able to comply with the study requirements
Exclusion criteria
✕. Ankle-Brachial Index \>0.9 or \<0.4
✕. isolated disease in aorta/iliac vessels
✕. unstable angina or myocardial infarction in past 12 months
✕. orthopedic or other physical limitations which would prevent data collection
✕. contraindications to MRI, including presence of a Pacemaker, presence of bone growth/ bone fusion stimulators, presence of tissue expander, presence of cochlear implants, unable to ambulate for 10 feet, receiving continuous Oxygen therapy, pregnancy, permanent Jewelry (screened using MRI safety screening form and verbal screening by MRI operator
✕. unstable angina or myocardial infarction in past 12 months
✕. orthopedic or other physical limitations which would prevent data collection
✕. contraindications to MRI, including presence of a pacemaker, presence of bone growth/ bone fusion stimulators, presence of tissue expander, presence of cochlear implants, unable to ambulate for 10 feet, receiving continuous Oxygen therapy, pregnancy, permanent Jewelry (screened using MRI safety screening form and verbal screening by MRI operator).