The purpose of this study is to characterize andexanet posology and interaction between andexanet and enoxaparin post infusion in healthy participants.
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Anti-Factor (F) Xa activity
Timeframe: Day 1 post dose
Change from baseline in anti-FXa activity
Timeframe: Day 1 post dose
Thrombin generation potential
Timeframe: Day 1 post dose
Change from pre-direct oral anticoagulants (DOAC) in thrombin generation potential
Timeframe: Day 1 post dose
Change from baseline in thrombin generation potential
Timeframe: Day 1 post dose
Time to onset of coagulation
Timeframe: Day 1 post dose
Change from pre-DOAC in time to onset of coagulation
Timeframe: Day 1 post dose
Change from baseline in time to onset of coagulation
Timeframe: Day 1 post dose
AstraZeneca Clinical Study Information Center
Anti-FXa activity following enoxaparin dosing
Timeframe: From Day 1 to Day 2
Thrombin generation potential following enoxaparin dosing
Timeframe: From Day 1 to Day 2