Pharmacokinetics of Didehydro-LSD (DDH-LSD) Compared With LSD (NCT07309471) | Clinical Trial Compass
RecruitingNot Applicable
Pharmacokinetics of Didehydro-LSD (DDH-LSD) Compared With LSD
Switzerland24 participantsStarted 2026-03-06
Plain-language summary
This study investigates DDH-LSD, a novel LSD-like compound expected to have a shorter duration of action than LSD. In healthy volunteers, pharmacokinetics, safety, and subjective effects, will be assessed and compare with LSD in a controlled cross-over study.
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Age between 25 and 65 years old
. Sufficient understanding of the German language
. Understanding of procedures and risks associated with the study
. Willing to adhere to the protocol and signing of the consent form
. Willing to refrain from the consumption of illicit psychoactive substances during the study
. Abstaining from xanthine-based liquids from the evenings prior to the study sessions and during the sessions
. Willing not to operate heavy machinery within 48 h of substance administration
. Willing to use effective contraceptive measures throughout study participation
Exclusion criteria
. Chronic or acute medical condition
. Current or previous major psychiatric disorder
. Psychotic disorder or bipolar disorder in first-degree relatives
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Determine effective DDH-LSD dose
Timeframe: During each 13-hour study session.
2
Compare duration of action and elimination half-life