Subendometrial Injection Versus Intrauterine Infusion of Platelet Rich Plasma for Women With Recu… (NCT07306871) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Subendometrial Injection Versus Intrauterine Infusion of Platelet Rich Plasma for Women With Recurrent Implantation Failure
Egypt180 participantsStarted 2026-01-01
Plain-language summary
Aim of this study is to compare the effectiveness of subendometrial PRP injection \& intrauterine PRP infusion in women with recurrent implantation failure in comparison with a control group .
Who can participate
Age range18 Years – 40 Years
SexFEMALE
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Inclusion Criteria:
* Age 18 -40 years .
* BMI\<30 Kg/m2.
* An IVF procedure resulting in at least one top quality embryo .
* At least one cancelation history of embryo transfer due to thin endometrium (failure of achieving 7 mm endometrial thickness in the cycle) in frozen embryo transfer (FET) cycles after receiving standard hormone therapy.
* Women had a history of failure to achieve pregnancy after two or more embryo transfers with high-quality embryos.
Exclusion Criteria:
* women with other factors that may affect implantation success are excluded: ;
* BMI \>30 kg/m2.
* Untreated uterine abnormalities.
* untreated hydrosalpinges.
* Thrombophilia.
* uncontrolled endocrinopathy
* severe male factor infertility.
* difficult embryo transfer.
* only poor quality embryos available .
* couple with chromosomal abnormalities
* Hematological disorders (blood cancer ,thrombocytopenia )
* Hormonal disorders (DM,thyroid disorders )
* Immunological disorders (anti phospholipid syndrome).
* renal failure
* Genetic ,chromosomal abnormalities