Active — Not RecruitingNot Applicable

Subendometrial Injection Versus Intrauterine Infusion of Platelet Rich Plasma for Women With Recurrent Implantation Failure

Egypt180 participantsStarted 2026-01-01

Plain-language summary

Aim of this study is to compare the effectiveness of subendometrial PRP injection \& intrauterine PRP infusion in women with recurrent implantation failure in comparison with a control group .

Who can participate

Age range

18 Years – 40 Years

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age 18 -40 years . * BMI\<30 Kg/m2. * An IVF procedure resulting in at least one top quality embryo . * At least one cancelation history of embryo transfer due to thin endometrium (failure of achieving 7 mm endometrial thickness in the cycle) in frozen embryo transfer (FET) cycles after receiving standard hormone therapy. * Women had a history of failure to achieve pregnancy after two or more embryo transfers with high-quality embryos. Exclusion Criteria: * women with other factors that may affect implantation success are excluded: ; * BMI \>30 kg/m2. * Untreated uterine abnormalities. * untreated hydrosalpinges. * Thrombophilia. * uncontrolled endocrinopathy * severe male factor infertility. * difficult embryo transfer. * only poor quality embryos available . * couple with chromosomal abnormalities * Hematological disorders (blood cancer ,thrombocytopenia ) * Hormonal disorders (DM,thyroid disorders ) * Immunological disorders (anti phospholipid syndrome). * renal failure * Genetic ,chromosomal abnormalities

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Implantation rate

Timeframe: 5 weeks after embryo transfer

Trial details

NCT IDNCT07306871

SponsorMinia University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-12

View on ClinicalTrials.gov More Recurrent Implantation Faliure trials