Not Yet RecruitingNot Applicable

Effectiveness of Hydrogen Water Intervention on Acute Oral Inflammation, Oral Microbiota, and Pain Following Free Flap Reconstruction in Patients With Oral Cancer

36 participantsStarted 2026-01

Plain-language summary

This study employs a Randomized Controlled Trial (RCT) design. Patients diagnosed with oral cancer by the attending physician and who meet the inclusion criteria will be admitted to the study after receiving a full explanation of the study objectives, intervention methods, potential risks, and participant rights from the research team upon their stable transfer to the plastic surgery ward post-operation. Written consent will be obtained from the patient and/or their legally authorized representative after adequate informed consent has been provided, before they are enrolled in the study.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Diagnosed with oral cancer and receiving microsurgical free flap reconstruction. * Age 18 years or older. * Conscious and able to follow study instructions. * Able to communicate without difficulty in Mandarin, Taiwanese, or through written communication. Exclusion Criteria: * Abnormal salivary gland function or severe xerostomia. * Recent use of antibacterial mouthwash or antibiotic therapy that may affect oral microbiota. * Presence of severe bacterial or viral oral infections, or significant periodontal disease.

What they're measuring

IL-1β、IL-6、IL-10、TNF-α

Timeframe: Baseline (T0) and Day 7 (T1)

Oral Assessment Guide (OAG) Score

Timeframe: Baseline (T0) and Day 7 (T1)

Trial details

NCT IDNCT07306546

SponsorKaohsiung Medical University Chung-Ho Memorial Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-10-31

Contact for this trial

I-SHAN CHOU, MS

+886-917-520-113 awoponn20@gmail.com