Researchers are looking for new ways to treat people with solid tumors, lymphomas (blood cancers), and a certain type of skin cancer. The goals of this study are to learn: * About the safety of pembrolizumab (the study medicine) and if people tolerate it * What happens to different doses of pembrolizumab in a person's body over time * How the cancer responds (gets smaller or goes away) to treatment
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Arm 1: Number of Participants Who Experience an Adverse Event (AE)
Timeframe: Up to approximately 28 months
Arm 1: Number of Participants Who Discontinue Study Treatment Due To an AE
Timeframe: Up to approximately 25 months
Arm 1: Area Under the Concentration-Time Curve (AUC) of Pembrolizumab
Timeframe: Predose at Cycle 1, 2, 4, 8 and every 4 cycles thereafter up to 35 cycles; postdose at Cycle 1 and Cycle 8 (a cycle is 21 days)
Arm 1: Maximum Concentration (Cmax) of Pembrolizumab
Timeframe: Predose at Cycle 1, 2, 4, 8 and every 4 cycles thereafter up to 35 cycles; postdose at Cycle 1 and Cycle 8 (a cycle is 21 days)
Arm 1: Minimum Plasma Concentration (Cmin) of Pembrolizumab
Timeframe: Predose at Cycle 1, 2, 4, 8 and every 4 cycles thereafter up to 35 cycles; postdose at Cycle 1 and Cycle 8 (a cycle is 21 days)
Arm 2: Objective Response Rate (ORR) per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) by Blinded Independent Central Review (BICR)
Timeframe: Up to approximately 37 months