The Effect of Exercise and Tirzepatide on Weight and Health Outcomes (EXER-MED) (NCT07298915) | Clinical Trial Compass
Not Yet RecruitingPhase 3
The Effect of Exercise and Tirzepatide on Weight and Health Outcomes (EXER-MED)
United States24 participantsStarted 2026-08
Plain-language summary
This is clinical trials is to evaluate the effect of exercise with weight loss medication compared to weight loss alone. The study will enroll 24 adults from 30-65 years old with overweight or obesity.
The main questions it will answer includes:
* Does exercise combined with weight loss medication reduce body weight and body fat more than weight loss medication alone
* Does exercise combined with weight loss medication improve other risk factors more such as the sugar in the blood, cholesterol, fitness, and quality of life
Participants will:
* Take a weight loss medication (tirzepatide) monthly under the supervision of their primary care physician
* (Exercise group only) Will perform exercise \~3 times a week at the University of Virginia). Walking on a treadmill and resistance training
* Visit the study site at the beginning of the study and after the study to evaluate weight, body fat, and other health measures
Who can participate
Age range30 Years – 65 Years
SexALL
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Inclusion Criteria:
* Men and women 30-65 years of age, postmenopausal women included
* 27-29.9 with an additional CVD risk factor or 30-40 kg/m2
* For overweight adults only: additional cardiometabolic risk factor (diagnosed dyslipidemia, hypertension)
* Willingness and adequate health to go on weight loss medication
* The capability and willingness to provide written informed consent
* Approval of their primary care provider to go on weight loss medication
Exclusion Criteria:
* Including but not limited to serious arrhythmias
* Cardiomyopathy
* Congestive heart failure
* Stroke or transient ischemic attacks
* Peripheral vascular disease
* Previous history of myocardial infarction or stroke
* Previous diagnosis or taking medication for type 1 or 2 diabetes, fasting glucose \>125 mg/dL or HbA1C ≥6.5%
* Systolic blood pressure \>160 mmHg and diastolic blood pressure \>100 mmHg.
* Hospitalization for mental illness within the past 5 years or currently undergoing treatment for severe mental illness
* Conditions that can be aggravated or are contraindicated by exercise training
* Plans to be out of town more than 3 weeks in the next 4 months.
* Currently pregnant or plans to become pregnant
* Currently in a diet or exercise program
* Non-compliance during screening or extreme difficulty in obtaining baseline blood samples
* Enrolled in a different exercise program
* Previous weight loss surgery
* Use of weight loss medication within the last year
* hypo/hyper thyroid (medicate…