3 mL Inhaled Methoxyflurane for Intrauterine Device (IUD) Insertion (NCT07295054) | Clinical Trial Compass
RecruitingPhase 4
3 mL Inhaled Methoxyflurane for Intrauterine Device (IUD) Insertion
Canada110 participantsStarted 2026-04
Plain-language summary
Intrauterine device (IUD) insertion is a common contraceptive procedure often associated with moderate to severe pain, particularly among nulliparous individuals. Current pain management strategies, such as over-the-counter analgesics, are frequently inadequate. Methoxyflurane, a short-acting, self-administered inhaled analgesic, has been shown to provide rapid and effective pain relief in acute and procedural settings. This study aims to evaluate whether 3 mL of inhaled Methoxyflurane (via Penthrox inhaler) improves patient satisfaction by reducing pain and anxiety during IUD insertion.
Who can participate
Age range18 Years – 55 Years
SexFEMALE
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Inclusion criteria
✓. Patients with a uterus.
✓. Ages 18 to 55 years.
✓. Undergoing any intrauterine device (IUD) insertion.
✓. English-speaking participants.
✓. Ability to use an inhaler device.
✓. Willing to receive a cervical block for their IUD insertion
Exclusion criteria
✕. Inability to provide informed consent.
✕. Confirmed pregnancy.
✕. Use of pain medication other than NSAIDs or acetaminophen (e.g., opioids, benzodiazepines, muscle relaxants) within 24 hours prior to the intervention.
✕. Use of cannabis within 24 hours prior to the intervention.
✕. Administration of misoprostol within 24 hours prior to the intervention.
✕. Altered level of consciousness due to any cause, including head injury, drugs, or alcohol.
✕. History of severe adverse reactions to Penthrox (methoxyflurane) or other halogenated anesthetic agents, or to any ingredient in the formulation (including non-medicinal ingredients or container components).
✕. Anatomical variance, such as distorted uterine cavity, bicornuate uterus, uterus didelphys, or cervical stenosis.