Elevated sclerostin levels in serum and alveolar bone of osteoporotic patients may exert deleterious effects on the periodontium, thereby contributing to the progression and increased severity of periodontal disease. Moreover, sclerostin is considered a potential biomarker for elucidating the shared pathophysiological mechanisms linking postmenopausal osteoporosis and periodontitis
Who can participate
Age range43 Years – 78 Years
SexFEMALE
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Female patients aged 40 years and older in the postmenopausal period,
* Individuals diagnosed with osteoporosis or healthy individuals without osteoporosis, as determined by DXA testing of the hip or spine,
* Individuals who had been postmenopausal for ≥6 months and had not received hormone replacement therapy,
* Patients who did not smoke or consume alcohol,
* Female patients who were periodontally healthy or diagnosed with Stage 2-3, Grade A periodontitis
Exclusion Criteria:
* Patients with chronic renal and hepatic insufficiency; malignant diseases such as diabetes mellitus, leukemia, multiple myeloma, and widespread carcinoma; chronic inflammatory rheumatic diseases such as rheumatoid arthritis and ankylosing spondylitis; and those using drugs that may affect bone metabolism (glucocorticoids, heparin, methotrexate, anticonvulsants),
* Those who had received antibiotic therapy in the previous 3 months or any medication for osteoporosis treatment,
* Patients who had undergone surgical or non-surgical periodontal treatment within the previous 6 months,
* Patients who did not wish to continue participation in the study at the midpoint or at the end of the study.
What they're measuring
1
Serum Sample Collection
Timeframe: 6 month
2
Collection and Quantification of Gingival Crevicular Fluid Samples