IMPAACT 2046/UPLIFT (Understanding Practices of Lactation and Infant Feeding decisions Together with women with HIV) is a multi-site, mixed-methods, observational cohort study. The purpose of the study is to explore infant feeding preferences, practices, and outcomes among mothers with HIV and their families in the United States. It will employ both qualitative and quantitative research methods to address existing knowledge gaps and to understand the clinical, behavioral, and social factors influencing infant feeding decisions. As part of the study's mixed method approach, a longitudinal cohort study of mothers and their infants will be established. The study also aims to pilot a national registry of breastfeeding women living with HIV in the United States.
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CA 1: Factors influencing infant feeding decision
Timeframe: Within 28 days and 2 years of Enrollment
CA 1: Infants born to women with HIV who receive any breast milk
Timeframe: Monthly, through study completion, up until 5 years
CA 2: Infant feeding method chosen
Timeframe: At 48 weeks post birth
CA 2: Breastfeeding initiation among those who intended to breastfeed
Timeframe: At 48 weeks post birth
CA 2: Duration of breastfeeding among PPWH who breastfeed
Timeframe: Through 96 weeks post birth
CA 2: Completion of intended duration of breastfeeding
Timeframe: Through 96 weeks post birth
CA 2: Mixed method analysis of infant feeding practices from in-depth interviews and survey data
Timeframe: At 48 weeks post birth
CA 2: Breast milk samples with detectable HIV DNA or RNA
Timeframe: Through 48 weeks post birth; At weaning up to 96 weeks post birth
CA 2: Viral load measured in different breast milk compartments
Timeframe: Through 48 weeks post birth; At weaning up to 96 weeks post birth
CA 3: Data completed in registry
Timeframe: Through study completion, an average of 3 years
CA 3: Median score on Feasibility of Intervention Measure, Acceptability of Intervention Measure and Appropriateness of Intervention Measures
Timeframe: Through study completion, an average of 3 years
CA 3: Completion of two visit entries for at least three eligible participants
Timeframe: Through study completion, an average of 3 years